insights into the possible mechanism of cyclosporine-induced chronic nephrotoxicity; arteriolopathy

Insights into the Possible Mechanism of Cyclosporine-Induced Chronic Nephrotoxicity; Arteriolopathy

I read with great interest the recent contribution by Uz et al. (1) that demonstrated the protective effects of erdosteine on cyclosporine (CsA)-induced chronic nephp-rotoxicity in rats. The authors however, did not suggest the possible mechanism of nephrotoxicity or the recent reports concerning the action of antioxidants on neph-rotoxicity. I would like to add some considerations on the notew...

Cyclosporine A induced arteriolopathy in a rat model of chronic cyclosporine nephropathy.

Chronic cyclosporine (CsA) nephrotoxicity is a major complication of heart, bone marrow, and renal transplantation, and is characterized in humans by striped interstitial fibrosis, tubular dilatation and atrophy, and hyalinization of hilar arterioles. This last feature is highly specific for cyclosporine injury and has been difficult to reproduce in normotensive animal models. Salt-depletion ha...

Effect of Erdosteine on Cyclosporine Induced Chronic Nephrotoxicity

Drugs and exogenous toxins, including aminoglyco-sides, amphotericin B, cisplatin, and radiocontrast media , may cause acute kidney injury (1). The manifestations which indicate that damage is occurring are a sudden increase in kidney injury biomarkers (NGAL [neutrophil gelatinase-associated lipocalin], KIM-1 [kidney injury molecule-1], etc.) and kidney failure (creatinine, cystatin C). This im...

effect of erdosteine on cyclosporine induced chronic nephrotoxicity

New insights into the pathophysiology of cyclosporine nephrotoxicity: a role of aldosterone.

Cyclosporine A (CsA), a calcineurin inhibitor, has improved allograft survival in solid organ transplantation and has been increasingly applied in the management of autoimmune diseases. While marked progress has been made in patient and allograft survival rates, clinical use of CsA is often limited by its nephrotoxic effect, which can be presented as two distinct and well-characterized forms: a...

New insights into Pathophysiology of Cyclosporine Nephrotoxicity: A role of aldosterone

Cyclosporine A, a calcineurin inhibitor, has improved allograft survival in solid organ transplantation and has been increasingly applied in the management of autoimmune diseases. While marked progress has been made in patient and allograft survival rates, clinical use of CsA is often limited by its nephrotoxic effect, which can be presented as two distinct and well characterized forms: acute a...